Haemoglobin is a paradigm for exploring allosteric regulation, wherein ligand binding at one site induces conformational changes that affect functional activity at a distant site. These structural ...

How proteins evolved the ability to form complexes made up of multiple subunits—and what functions this new structure enabled in early multimeric proteins—isn’t well understood. To better understand ...

ARLINGTON, Va.– Red-blooded genealogists take note: The discovery in microbes of two oxygen-packing proteins, the earliest known ancestors to hemoglobin, brings scientists closer to identifying the ...