A recent study led to the development of a powerful epigenetic editing technology. The system unlocks the ability to precisely program chromatin modifications at any specific position in the genome, ...
This Brush Up is sponsored by Cayman Chemical. Learn more about chemical inhibitors of histone modification. Histone modification affects how tightly DNA wraps around histone proteins, yielding ...
Genotoxic stress impairs plant development. To circumvent DNA damage, plants activate DNA repair pathways in concert with chromatin dynamics. These are essential during seed germination and seedling ...
Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...
Genes are regulated by complex interactions involving transcription factors, DNA regulatory regions, and epigenetic modifications which alter chromatin structure. Modifications to chromatin regulate ...
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