Assessments of DNA misrepair, and the resulting effects on the structural integrity of the genome, are critical for evaluating the safety of cell and gene therapy applications. Most genome editing ...

For successful cell division, chromosomal DNA needs to be packed into compact rod-shaped structures. Defects in this process can lead to cell death or diseases like cancer. A new study has shown how ...

Genome assemblies from 65 individuals, representing a variety of the world’s populations, are advancing the scientific exploration of complex genetic structural variation. Structural variations are ...

Researchers are making strides in understanding how chromosome structures change throughout the cell's life cycle. Researchers at Rice University are making strides in understanding how chromosome ...

An international team of scientists has decoded some of the most stubborn, overlooked regions of the human genome using complete sequences from 65 individuals across diverse ancestries. This milestone ...

New analysis of the 1000 Genomes sample set yields brand new insights, providing a more complete view of human genetic variation than ever before. Completed in 2003, the Human Genome Project gave us ...

Researchers at Rice University are making strides in understanding how chromosome structures change throughout the cell's life cycle. Their study on motorized processes that actively influence the ...

One of the challenges of working with ancient DNA samples is that damage accumulates over time, breaking up the structure of the double helix into ever smaller fragments. In the samples we've worked ...