49ers vs Colts final score, results: Brock Purdy throws five touchdowns, 49ers control destiny after win vs. Colts originally appeared on The Sporting News. Add The Sporting News as a Preferred Source by clicking here. The San Francisco 49ers have officially put their playoff destiny in their own hands.

The Indianapolis Colts are switching things up at quarterback for their Week 18 clash with the Houston Texans.

The Indianapolis Colts, led by rookie quarterback Riley Leonard, face the Houston Texans, led by quarterback C.J. Stroud, on Sunday, Jan. 4, 2026 at NRG Stadium in Houston, Texas.

The Houston Texans have pulled quarterback C.J. Stroud from their Week 18 game versus the Indianapolis Colts. Houston decided to remove Stroud from the contest on their opening drive of the third quarter for Davis Mills. Let's take a look at why the Texans made this move.

The San Francisco 49ers offense is cruising and they were dominant in a win over the Indianapolis Colts. Here are the highlights.

The NFL season continues in Week 18 when the Houston Texans host the Indianapolis Colts on Sunday. Start time, how to watch, stream and NFL TV schedule.

Indianapolis Colts' wide receiver Alec Pierce was ejected in Sunday's Week 18 game against the Houston Texans. Pierce was ejected for making contact with an official. But you be the judge. Here is how the rule is written in the NFL rulebook and is supposed to be enforced.

The second half of the NFL season couldn't have gone worse for the Indianapolis Colts. Their starting quarterback suffered a season-ending injury, they lost seven consecutive games, and the star cornerback they traded two first-round picks for played just two full games.

“Do you still have your juju, your shimmer, to do this?” This is Ballard telling the story late Thursday morning at the Colts’ complex on 56 th Street, three days after Irsay-Gordon had sat at the same dais, spoken into the same microphone, and told Colts fans what the loudest faction did not want to hear:

Get the best Colts vs. Texans predictions ahead of Sunday's AFC South finale at NRG Stadium. Free NFL picks for January 4.

Jones began his tenure in Indy as the presumed backup, though things changed during training camp. Eventually, much to the surprise of the general public, coach Shane Steichen opted to go with Jones as the team's Week 1 starter, demoting 2023 first-round pick Anthony Richardson.

It wasn't C.J. Stroud, Dalton Schultz, Woody Marks or Jayden Higgins who scored a touchdown on the final play of the Houston Texans' 38-30 victory over the Indianapolis Colts.