Cryo-EM structures reveal conformational dynamics behind AP-4 membrane trafficking

Adaptor protein (AP) complexes play central roles in intracellular vesicular trafficking by coupling cargo selection to ...
EurekAlert!

Cryo-EM structures of Nipah virus polymerase complex reveal highly varied interactions between L and P proteins among paramyxoviruses

Toward the goal of efficient editing of farm animals for genetic improvements, this study explores an upgraded form of nuclease PE (uPEn). Based on the resolved structure of the NiV polymerase L-P ...

Biopsy-derived cryo-EM structures reveal patient-specific amyloid fibrils

Prof. Liu Cong from the Shanghai Institute of Organic Chemistry of the Chinese Academy of Sciences, along with collaborators, has revealed the high-resolution structures of amyloid fibrils directly ...
National Academies of Sciences%2c Engineering%2c and Medicine

Unique Capabilities of Cryo-EM in Structure Determination and its Potential in Drug Discovery

The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide expert advice on some of the most pressing challenges facing the nation and world. Our ...
Labroots

Next-Gen Cryo-EM: Advancing Cellular and Structural Biology

Cryo-electron microscopy (cryo-EM) has revolutionalized our understanding of the intricate molecular machinery that governs life. It has elucidated the three-dimensional (3D) structure of biological ...
The Scientist

Integral HIV Protein Structure Paves the Way for New Therapeutics

HIV is a lifelong infection that, without proper antiviral treatment, will kill cells of the immune system and leave individuals susceptible to infections and cancers. The longevity of this virus ...