Alt-Tab is a built-in OS function and hence, you cannot disable it per se, unless you modify the registry. But, as an easier alternative, you can remap/rebind the key while in the game. In this post, ...

I want to disable the new graphical ALT+TAB interface, since it is pretty sluggish compared to the older version of ALT+TAB. It popped up when I installed build 2.0.0 of PowerToys for XP.<P>TweakUI ...