Scientists watch cell receptors respond in real time as drugs bind

A research team of the University Medical Center Mainz has succeeded in observing for the first time how G protein-coupled ...
Phys.org

Flexibility is function: How unstructured protein segments regulate biological functions

Researchers have discovered how unstructured segments of surface proteins regulate the biological function of a cell. Their study, published in Nature Communications, sheds new light on the interplay ...
EurekAlert!

Structural findings reveal how distinct GPCR ligands create different levels of activation

Corresponding author Georgios Skiniotis, PhD, St. Jude Center of Excellence for Structural Cell Biology director and Department of Structural Biology member. (MEMPHIS, Tenn. – December 22, 2025) ...
BioTechniques

How it works: the dynamic G protein-coupled receptor

A GPS-like technique has been used to track G protein-coupled receptor movement, revealing how these essential receptors function. Although G protein-coupled receptors (GPCRs) are crucial to the ...
EurekAlert!

Identification of regulatory GPCRs by single-cell trajectory inference

This study is reported by Changtao Jiang’s group and Dongyu Zhao’s group from School of Basic Medical Sciences, Peking University. Adipogenesis is the healthy expansion of white adipose tissue (WAT), ...
Business Wire

Septerna Secures $150 Million in Series B Financing to Advance Pipeline of Novel GPCR-targeted Medicines

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Septerna, a biotechnology company discovering and advancing novel oral small molecule medicines targeting G protein-coupled receptors (GPCRs), today ...