However,instead of attacking cancer cells, they are typically co-opted to support tumor growth, metastasis, and therapeutic ...
Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center for Cancer Biology and ...
Metabolic reprogramming is a defining hallmark of breast cancer, encompassing diverse alterations in energy utilisation, biosynthetic pathways and intracellular signalling. Tumour cells frequently ...
AbstractNon apoptotic cell death programs particularly ferroptosis and cuproptosis are transforming how we understand cancer ...
Tumor-associated macrophages (TAMs) are immune cells that tumors hijack to fuel their own growth and evade immune attack. A ...
Breast cancer development is not solely the result of cancer cells acting independently, it involves a dynamic and complex ecosystem composed of cancer cells, immune cells, fibroblasts, adipocytes, ...
The concept of trained immunity has redefined innate immune responses as adaptable, durable, and context dependent. Natural killer (NK) cells, traditionally ...
Aerobic glycolysis dominates lesion bioenergetics, with lactate promoting histone lactylation, M2 macrophage polarization, CD8⁺ T-cell exhaustion, EMT, and fibrosis that reinforce immune-protected ...
Breast cancer remains the most prevalent malignancy among women worldwide, posing a critical challenge to global health. Amid the complexities of this disease, an emerging focus on metabolic ...
Leuven, 11 March 2025 – Solid tumors often provide a challenging environment for the T cells of our immune system. By reprogramming the metabolism of T cells, scientists at the VIB-KU Leuven Center ...
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