Maintaining cellular order is a major logistical challenge: Individual mammalian cells contain billions of protein molecules, ...

Undruggable targets typically refer to a class of therapeutic targets that are difficult to target through conventional methods or have not yet been targeted, but are of great clinical significance.

Targeted protein degradation has opened up a new field of drug discovery with potential to treat previously 'undruggable' diseases. The work means new drugs can be much more accurately targeted at the ...

Targeted protein degradation (TPD) is transforming drug discovery by leveraging the cell’s natural protein disposal systems to eliminate disease-causing proteins. Innovators are making rapid and ...