Advancing RNA therapeutics depends on understanding two critical questions: Where do drug candidates go, and what do they do ...

Neurons exhibit a remarkable level of cellular compartmentalisation that underpins their complex signalling capabilities and functional adaptability. A key component of this spatial organisation is ...

While great strides have been made in exploring the world of RNA, mysteries remain—and one approach to solving them is to look at what exactly a strand of RNA is doing in a cell in real time. At a ...

CRISPR-Cas13, a powerful RNA-targeting technology is gaining increasing attention as a next-generation gene therapy platform due to its precision and reduced side effects. Utilizing this system, ...

Osaka, Japan – Systemic autoimmune diseases are characterized by inflammation of multiple organs and can have devastating consequences for patients. There is a dire need for treatments against these ...

The Wilusz Lab aims to understand how noncoding RNAs are generated, regulated, and function. We take advantage of high-throughput approaches coupled to detailed biochemical studies to characterize ...

When a neuron in our body gets damaged, segments of RNA produce proteins that can help repair the injury. But in neurological disorders such as ALS and spinal muscular atrophy, or following spinal ...

This study provides a comprehensive evaluation of the off-target effects of ADARdd and provides guidelines for improving RNA editing accuracy in plants. The authors also emphasize that ...