Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...

The structural integrity of DNA is continually being challenged due to the presence of physical and chemical carcinogens in our environment. In addition to DNA lesions caused by exogenous agents, DNA ...

Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian cancers. Mechanistic insight into the functions of human BRCA2 has been limited by the difficulty of isolating ...

Sometimes the most stunning advances in science are based on a hunch that a dedicated investigator just can’t shake. That was the case with Mary-Claire King, professor of genome sciences and of ...

One of the biggest challenges in cancer treatment is chemoresistance: Tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often ...

The past decade has witnessed a rapid expansion of genetic tests, including new instruments to inform patients who have been diagnosed with breast cancer about the risk of recurrence and to guide ...

BRCA1 and BRCA2 are genes that help prevent tumors from growing. If you inherit a change, or mutation, in these genes, they stop doing their jobs, and cancer can develop. In the United States, about 1 ...

Akeega combines niraparib, a PARP inhibitor, and abiraterone acetate, a CYP17 inhibitor, into a single tablet for BRCA2-mutated mCSPC.

Women with a family history of breast cancer make up about 15% of all women with the disease. Having a close relative (mother, sister, or daughter) with breast cancer doubles your risk compared to ...

What Is Akeega, and Why Does It Matter? Akeega is a dual-action tablet combining two medicines — niraparib and abiraterone acetate — that has been approved by the FDA in combination with prednisone (a ...

Court rules unanimously that Myriad Genetics "did not create anything." June 13, 2013 -- The Supreme Court ruled today that isolated human genes cannot be patented, a partial defeat for Myriad ...

Researchers found that losing a second protein, FIGNL1, allows cancer cells missing BRCA2 to restore DNA repair by reloading RAD51 onto broken DNA strands. Normally, BRCA2 helps place RAD51 at DNA ...