A research team has uncovered and reconstructed the complete biosynthetic pathway of polyphyllin II—a potent anticancer ...

Machine learning models reveal that histone marks are predictive of gene expression across human cell types and highlight important nuances between natural control and the effects of CRISPR-Cas9-based ...

It's a common storytelling trope: the stubborn foe who is eventually revealed to be a much-needed friend. Biology has its own version. Cornell researchers have discovered that DNA packaging structures ...

Northwestern Medicine scientists have discovered how molecular "traffic controllers" in cells influence aging and cellular senescence—a state where cells stop dividing but remain metabolically active.

The code base for our work on improving the performance of sequence-to-expression models for making individual-specific gene expression predictions by fine-tuning them on personal genome and ...

The authors collected time-course RNA-seq data from four tree species in natural environments and analyzed seasonal patterns of gene expression. This fundamental study substantially advances our ...

All the cells in an organism have the exact same genetic sequence. What differs across cell types is their epigenetics—meticulously placed chemical tags that influence which genes are expressed in ...

What if you could flip a genetic switch to silence a gene, then turn it back on with a simple drug? For researchers, gene-switch tools offer that kind of control—and a new system called Cyclone may ...

Introduction: RNA sequencing (RNA-seq) can measure whole transcriptome gene expression from tissues or even individual cells, providing a powerful tool to study the immune response. Analysis of ...

Background: Oral squamous cell carcinoma (OSCC) is a challenging malignancy with poor prognosis despite therapeutic advancements. This study seeks to derive a precise molecular subtyping and ...