There are 3 steps to the haemostasis pathway: 1. vascular spasm, 2. platelet plug formation, 3. blood coagulation. Vascular spasm - vasoconstriction of the smooth muscle within the walls of the vessel is the body's first response to bleeding. The vascular spasm response is believed to be triggered by several chemicals called endothelins that are released by vessel lining cells and by pain receptors response to vessel injury. This phenomenon typically lasts for up to 30 minutes, although it can l
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